International Natural Product Sciences Taskforce (INPST)

Abstract The aim of the present study was to determine the chemical composition, antibacterial and antibiofilm activities of the essential oil of sawdust from root burl wood of T. articulata. Nine strains including 8 clinical isolates from catheters-related infections and one ATCC 25923 were tested. Twenty-seven different compounds were identified by GC-MS in the essential … Continue reading "In vitro antibacterial and biofilm inhibitory activity of the sawdust essential oil of Tetraclinis…

Social media: By Atanas G. Atanasov: Twitter, Facebook, LinkedIn, ResearchGate, and Instagram.

Abstract Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in … Continue reading "Magnesium Status and Stress: The Vicious Circle Concept Revisited"

Dear INPST colleagues, we are currently looking for a collaboration within our project focused on synthesis and biological evaluation of natural products from Selaginella genus and their derivatives and synthetic analogs. These compounds show prominent inhibitory activity against PDE4 enzyme and therefore, we are in particular interested to find a collaboration in this direction. Very … Continue reading "Collaboration call: Biological evaluation of natural products from Selaginella and their…

Abstract Background: The Thoracic Surgery Social Media Network (TSSMN) is a collaborative effort of leading journals in cardiothoracic surgery to highlight publications via social media. This study aims to evaluate the 1-year results of a prospective randomized social media trial to determine the effect of tweeting on subsequent citations and nontraditional bibliometrics. Methods: A total … Continue reading "Does Tweeting Improve Citations? One-Year Results From the TSSMN Prospective…

Abstract Harnessing CRISPR-Cas9 technology for cancer therapeutics has been hampered by low editing efficiency in tumors and potential toxicity of existing delivery systems. Here, we describe a safe and efficient lipid nanoparticle (LNP) for the delivery of Cas9 mRNA and sgRNAs that use a novel amino-ionizable lipid. A single intracerebral injection of CRISPR-LNPs against PLK1 … Continue reading "CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy"

Abstract Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” and used as seasoning and condiments globally. In addition to being an important food additive, black pepper is also used as a traditional medicine to treat vomiting, … Continue reading "Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine"

Abstract In this study, an ultrasensitive label-free nanobiosensor for detecting the Hepatitis C virus (HCV) RNA was fabricated, without the need for target denaturation, by using an RNA oligomer as a probe. The biosensor was prepared by electrodeposition of the copper oxide (Cu2O) and gold nanoparticles (AuNPs) on the nitrogen-doped graphene (NG) coated fluorine-doped tin … Continue reading "Label-free RNA-based electrochemical nanobiosensor for detection of Hepatitis C"

Abstract The kidney is essential for the physiological functions of the body. When exposed to high concentrations of toxins, these may induce the toxicity of the kidney (kidney injury), leading to renal failure and precipitating a condition called nephrotoxicity. The toxicity may result from hemodynamic changes and directly harm the cells and tissue, and causes … Continue reading "Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in…